Turnaround times
The quoted turnaround time is from sample receipt in the laboratory, to results authorisation in the Laboratory Information Management system. The times do not include transport of specimen to the laboratory or the administrative process to print and post/email reports. Service users must allow for transport and reporting time when ordering tests.
Clinical background:
Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare, life threatening, acquired haematopoetic stem cell disorder that affects all blood cell lineages. Somatic mutation of the X-linked phosphatidylinositol glycan complementation Class A (PIG-A) gene leads to partial or absolute deficiency of all proteins linked to the cell membrane by a glycol-phosphatidylinositol (GPI) anchor.
Specimen container paediatric:
pink top paediatric EDTA
Specimen container adult:
Purple top EDTA
Minimum volume paediatric:
0.5ml
Minimum volume adult:
0.5ml
Sample stability:
If kept at 4 degrees samples can be tested up to 3 days old
Transport requirements:
Ambient
Freq analysis:
6 monthly unless clinically indicated.
Add on test:
Use the contact details below to discuss if an add-on is required
Quality assurance:
UKNEQAS PNH
Reference ranges:
PNH clones should not be presentSensitivity for neutrophils and red blood cells is 0.01%.
Other info :
A neutrophil count is required.