Turnaround times
The quoted turnaround time is from sample receipt in the laboratory, to results authorisation in the Laboratory Information Management system. The times do not include transport of specimen to the laboratory or the administrative process to print and post/email reports. Service users must allow for transport and reporting time when ordering tests.
Clinical background:
May indicate primary hyperoxaluria if raised along with raised oxalate but is not specific for type 1.
New assay introduced to measure other metabolites in addition to glycolate that are excreted by patients with primary hyperoxaluria (PH). This replaces the previous glycolate assay and includes three additional analytes: glycerate, 4-hydroxy-2-oxoglutarate and dihydroxyglutarate.
We recommend measuring PH metabolites in cases of unexplained hyperoxaluria where it can help to identify those in whom genetic testing is indicated.
Specimen container paediatric:
Urine either random sample acidified to pH1 on receipt or aliquot from 24hour sample collected in acid.
Specimen container adult:
Urine either random sample acidified to pH1 on receipt or aliquot from 24hour sample collected in acid.
Minimum volume paediatric:
10 mL
Minimum volume adult:
10 mL
Special requirements:
Need to provide urine oxalate excretion result with request.
Reference ranges:
Glycolate excretion 140-620umol/24h (correct to 1.73m2 for children)Glycolate:creatinine ratio:
Under 1 yr: 1-49 μmol/mmol creatinine
1 – 4 years: 2-54 μmol/mmol creatinine
5 – 11 years: 1-68 μmol/mmol creatinine
>12 years: 14-57 μmol/mmol creatinineGlycerate:creatinine ratio
<100 μmol/mmol creatinineHOG:creatinine ratio
<11 μmol/mmol creatinineDHG:creatinine ratio
<40 μmol/mmol creatinine