Turnaround times
The quoted turnaround time is from sample receipt in the laboratory, to results authorisation in the Laboratory Information Management system. The times do not include transport of specimen to the laboratory or the administrative process to print and post/email reports. Service users must allow for transport and reporting time when ordering tests.
Clinical background:
Factor V Leiden is a variant form of human factor V that is associated with an increased risk of thrombosis. Due to the mutation, in which arginine is replaced with glutamine, activated protein C is unable to bind normally to activated factor V and downregulate the prothrombotic action, resulting in an increased thrombotic tendency. Factor V Leiden is the most common hereditary hypercoagulability disorder amongst ethnic Europeans
Specimen container paediatric:Light blue – sodium citrate (semi-transparent cap)
Specimen container adult:
Light blue- sodium citrate
Minimum volume paediatric:
Single whole blood sample
Minimum volume adult:
Single whole blood sample
Sample stability:
7 days at 4°C
Transport requirements:
Samples should be transported to the laboratory without delay
Freq analysis:
Fortnightly or urgent as required
Add on test:
[email protected] (external)
Quality assurance:
UK NEQAS Blood Coagulation
Reference ranges:
Prevalence in general population 5%
Prevalence in patients presenting with DVT or PE 30%
Other info:
Thrombotic riskHeterozygote 4 to 8 fold increase
Homozygote 40 to 80 fold increaseIncreased risk of thrombosis in pregnancy
Increased risk with Oestrogen containing oral contraception