Turnaround times
The quoted turnaround time is from sample receipt in the laboratory, to results authorisation in the Laboratory Information Management system. The times do not include transport of specimen to the laboratory or the administrative process to print and post/email reports. Service users must allow for transport and reporting time when ordering tests.
Clinical background:
Chronic Granulomatous Disease (CGD) is a primary immunodeficiency of defective neutrophil oxidative burst activity. It is caused by defects of NADPH oxidase, the enzyme responsible for the production of reactive oxygen species needed to kill pathogenic bacteria and fungi. NADPH oxidase has a membrane-bound flavocytochrome b558, which is comprised of gp91phox and p22phox and cytosolic components comprised of p40phox, p47phox and p67phox. Assays for gp91, p22, p47 and p67phox provide additional diagnostic information for CGD following initial abnormal testing by oxidative burst and NBT.
Specimen container paediatric:
pink top paediatric EDTA
Specimen container adult:
Purple top EDTA
Minimum volume paediatric:
2 mL
Minimum volume adult:
4 mL
Sample stability:
48 hours
Transport requirements:
Ambient
Freq analysis:
As required
Add on test:
Not possible
Reference ranges:
All CGD proteins should be normally expressed.