Turnaround times
The quoted turnaround time is from sample receipt in the laboratory, to results authorisation in the Laboratory Information Management system. The times do not include transport of specimen to the laboratory or the administrative process to print and post/email reports. Service users must allow for transport and reporting time when ordering tests.
Clinical background:
ANCA is a test for Granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis and may appear as either perinuclear (P-ANCA) or cytoplasmic (C-ANCA)
Specimen container paediatric:
Serum-Plain tube
Specimen container adult:
Serum-SST
Minimum volume paediatric:
0.5 ml
Minimum volume adult:
1 ml
Special requirements:
None
Availability:
Immunofluorescence ANCA is not routinely run, but may be specifically requested where the first-line tests for ANCA-related small vessel vasculitis – Myeloperoxidase (MPO) and Proteinase 3 (PR3) antibodies – are both Negative and there is still strong clinical suspicion of ANCA-related small vessel vasculitis.
Freq analysis:
Available on request
Add on test:
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address [email protected]
Quality assurance:
UK NEQAS for Autoimmune Serology ANCA and GBM
Interpretation:
90% of patients with WG will be positive for C-ANCA. P-ANCA is less specific and can be found in several forms of vasculitis. Serial monitoring of ANCA may help in the prediction of relapses.
Reference ranges:
Normal Range: Negative
Other info:
Reported as Negative or a titration value for Positive samples.