Turnaround times
The quoted turnaround time is from sample receipt in the laboratory, to results authorisation in the Laboratory Information Management system. The times do not include transport of specimen to the laboratory or the administrative process to print and post/email reports. Service users must allow for transport and reporting time when ordering tests.
Clinical background:
Lamotrigine (Lamictal) was first licensed for use as an anti-convulsant in 1994 for the treatment of partial seizures. It has now been licensed for use in monotherapy in adults and children, for both partial and primary and secondary tonic-clonic seizures. Lamotrigine is also widely used as a mood stabiliser in bipolar disorders. The measurement of lamotrigine levels is useful for tailoring treatment for an individual, particularly if poor compliance or toxicity are suspected. The half life of lamotrigine is around 25 hours, but this is significantly affected by many other drugs, especially other anti-convulsants such as carbamazepine, valproate and phenytoin. Large inter-individual variations in the dose/concentration exist and there is a therapeutic range in which lamotrigine is effective and unlikely to lead to severe side effects. Lamotrigine toxicity presents in a similar way to carbamazepine, and therapeutic drug monitoring can help in this diagnosis.
Specimen container paediatric:
EDTA or lithium heparin whole blood NO GEL separator
Specimen container adult:
EDTA or lithium heparin whole blood NO GEL separator
Minimum volume paediatric:
2 mL
Minimum volume adult:
2 mL
Special requirements:
Pre-dose or trough sample
Reference ranges:
3 – 15 mg/L