Clinical background:
Gastric parietal cell antibodies are found in patients with pernicious anaemia, they are associated with atrophic gastritis.
Specimen container paediatric:
Serum-Plain tube
Specimen container adult:
Serum-SST
Minimum volume paediatric:
0.5 ml
Minimum volume adult:
1 ml
Special requirements:
None
Freq analysis:
Daily
Add on test:
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address [email protected].
Quality assurance:
UK NEQAS for General Autoimmune Serology
Interpretation:
These antibodies may be found in individuals with normal full blood count and normal B12, however about 3% per year will go on to develop pernicious anaemia.
Reference ranges:
Normal Range: Negative
Other info:
Gastric parietal cell antibodies are reported as part of the Liver Autoantibodies screen as Negative, Weakly Positive, Positive or Strongly Positive. If an Anti-Mitochondrial Antibody (AMA) is detected, the GPC will be reported as ‘Not reportable in the presence of an AMA’ due to interfering staining from the AMA in the gastric parietal cells.
‘Not reporatble due to heterophilic staining’ due to the interfering heterophilic staing in the GPC.